Here we review concepts related to an ensemble description of G-protein-coupled receptors. The ensemble is characterized by both inactive and active states, whose equilibrium populations and exchange rates depend sensitively on ligand, environment, and allosteric factors. This review focuses on the adenosine A2 receptor, a prototypical class A GPCR. 19F Nuclear Magnetic Resonance studies show that apo A2AR is characterized by a broad ensemble of conformers, spanning inactive to active states, and resembling states defined earlier for rhodopsin. In keeping with (...) ideas associated with a conformational selection mechanism, addition of agonist serves to allosterically restrict the overall degrees of freedom at the G protein binding interface and bias both states and functional dynamics to facilitate G protein binding and subsequent activation. While the ligand does not necessarily “induce” activation, it does bias sampling of states, increase the cooperativity of the activation process and thus, the lifetimes of functional activation intermediates, while restricting conformational dynamics to that needed for activation. GPCRs represent a ubiquitous class of transmembrane receptors, responsible for cell signaling and cell homeostasis. Their activation gives rise to conformational changes that allow the receptor to engage downstream partners. Activation can be thought of in terms of a free energy landscape associated with distinct conformers, responsible for the process. Here, the action of ligands is seen to alter this landscape by enabling transitions between key intermediates. (shrink)

Volume I. Metaphysics and sport -- volume II. Ethics of sport -- volume III. Sport and the good life -- volume IV. Sport and education.

ABSTRACTIn this essay, I defend sport as a hobby in contrast to sport as a ‘mutual quest for excellence through challenge’. With the assistance of ideas found in the novel Don Quixote, I rai...

Many have written about trope ontology, but relatively few have considered its implications for some of the ontological conditions needed for us to have knowledge. I explore the resources of trope ontology to meet those conditions. With J. P. Moreland, I argue that, being simple, we can eliminate tropes’ qualitative contents without ontological loss, resulting in bare individuators. Then I extend Moreland’s argument, arguing that tropes undermine some of the needed ontological conditions for knowledge. Yet, we do know many things, (...) and trope nominalists presuppose that too. Therefore, I consider three counter-arguments, starting with David Lewis’s rebuttal based on appeal to brute facts. Second, I explore Jeffrey Brower’s recent proposal as a possible solution. Last, I consider Robert Garcia’s recent distinction between module and modifier tropes, to see if it can be of assistance. I conclude, however, that trope nominalism cannot preserve some of the needed ontology to have knowledge. (shrink)

The dominance of capitalism, through the hegemony of neoliberal ideology, is maintained as an illusion through the use of four main strategies. In order to obtain the consent of the population, mass schooling tends to produce graduates who accept this illusion because they are vulnerable to these strategies and cannot imagine a post-capitalist world. However, through education, people can better appreciate the problematic reality of unbridled capitalism, such as the degradation of the global ecosystem. It is argued here that programs (...) which are designed to address these problems, such as Education for Sustainable Development, are dependent upon citizens developing a critical consciousness. This consciousness is firstly able to confront the four strategies maintaining capitalism’s dominance. It is argued that an education which engages with spiritual ideals and values regarding how a good life is understood in an aspirational sense, enables people to engage with the dominance of capitalism and to envision other possibilities for society in which capitalism is harnessed to serve the greater public good. This requires education’s ontology – as the character of students – to critically read the world, imagine possibilities which can constitute a good life, and are courageous to enact the social actions required to make these ideals a reality. This is made possible by an education which returns to the spiritual roots of ideals. (shrink)

Volume 47, Issue 2, July 2020, Page 318-321.

Though nominalism is a major presupposition in academia and western society, R. Scott Smith shows that nominalism undermines all knowledge whatsoever. In light of the many clear examples of knowledge that we do have, nominalism should be replaced by a realist view of properties.

In this analysis, I employ Husserl’s three-part description of intentionality to show how a player/play act/play object model for consciousness helps us see play more clearly. I review Suits’ logic-based attempts to amend Huizinga’s overly inclusive characterization of play. However, I do so on what I see as stronger phenomenological grounds by describing four kinds of experience embedded in Suits’ work-play dichotomy. I analyze two species of play-fortified work – namely, work that requires intrinsic enhancement and work that does not. (...) I also describe two species of play – namely, play that is compromised and play that is unfettered. I conclude by summarizing advantages of phenomenological analyses and underlining the important distinctions this philosophic method uncovers within traditional work and play categories. (shrink)

The article is intended to reveal important similarities between fiction and sport. I build on Jonathan Gottschall’s discussion in The Storytelling Animal: How Stories Make Us Human by celebrating the significance of stories and their ‘witchy power’ and by examining factors that demonstrate similarities between fiction and sport. I suggest that an unmistakable semantic, structural, and cultural kinship exists between the two. This argument requires a discussion of play theory, play resources and constitutive rules, the semantic power of problems and (...) the uncertainty they produce, and the role of ‘frames’ in bringing problems to life. I conclude by noting the unique frame capabilities of ‘the big game’ and zero-sum dichotomous sporting motifs. (shrink)

If we attempt to unify the theoretical efforts that appreciate a specific social activity in play, we can sketch the perspective of an entire anthropology of play into cohesive parts deriving from the knowledge of collective experience. This preoccupation is, in fact, two-fold. On the one hand is the comprehensive description of the relationship between life styles and their stylizations in everyday practices and customs as well as in cultural works, and on the other are social sensitivities and representations that (...) are relatively shared by individuals grouped in human communities. This very general framework encourages situating the presence of play as one of the concrete manifestations of an emotional core, converting primitively negative impulses into attractive forces which, because of this, becomes the seat of all human interaction and agitation, the energetic heart of social power. (shrink)

William Lane Craig rejects Platonism (the view that uncreated abstract objects (AOs) exist) in favor of nominalism because he believes Platonism fatally compromises God’s aseity. For Craig, concrete particulars (including essences) exist, but properties do not. Yet, we use property-talk, following Carnap’s “linguistic frameworks.” There is, however, a high cost to Craig’s view. I survey his views and then explore the importance of essences. But, next, I show that his nominalism undermines them. Thus, we have just interpretations of reality. Worse, (...) nominalism undermines creation’s determinacy. Last, I suggest AOs are created, but in a more fundamental sense than Craig considers. (shrink)

It is important for educators to recognise that the various calls to decentre the subject—or self—should not be interpreted as necessarily requiring the removal of the subject altogether. Through the individualism of the Enlightenment the self was centred. This highly individualistic notion of the sovereign self has now been decentred especially through post‐structuralist literature. It is contended here however, that this tendency to decentre the subject has been taken to an extreme at times, especially by some designers of school frameworks (...) and curricula, who have eliminated the subject altogether. Such elimination is argued to contribute to the numbers of youth who are dropping out of school. By adopting an existential perspective and by drawing mainly upon Kierkegaard's subjective truth and Dewey's notion of centeredness, the case is made that for education the subject should not only be included but should actually be centred—at least momentarily. (shrink)

The purpose of this article is to attempt to discern better the situation of art in contemporary society. To do this we will examine essentially the exterior forces which influence it. These multiple and diverse evolutionary forces are in a certain manner centripetal, and ultimately they modify our concepts of art as such. Without going so far as to state that contemporary society has completely overturned our ideas on this question, signs of change are nevertheless visible which challenge fundamental characteristics (...) up until now attributed to art. (shrink)

If educators are to educate they must be accorded some level of trust. Anthony Giddens claims that because trust is not easily created, it is now being replaced with ‘confidence’ because this latter disposition is much easier to give and is more convenient. It is argued in this paper that this shift from trust to confidence stifles education because emphasis is placed solely upon qualifications and competence, and is neglectful of disclosing one’s motives and desires—which are considered to be essential (...) elements for relationships and communities which depend upon trust. Therefore, educators ought to seek to become more trustworthy by going beyond evidence-based practices and codes of ethics, towards articulating a developed personal philosophy of education outlining the ultimate end-purposes to which they aspire. Through such a philosophy, educators identify their ultimate desires and commitments and this self-disclosure can make trust-giving more likely. Demonstrated evidence of achievements and qualifications encourage confidence and this has some value. In addition to these artefacts of evidence, it is argued here that educators must also articulate what they actually desire. This can be understood as John Dewey’s virtue of ‘genuine interest’ which he characterises as being wholehearted, persistent and impartial. For educators, this is often represented in our personal philosophy of education and because it is personal, it is also existential in the sense that it pertains to giving sense, meaning and purpose to all of our activities and way of life for which we are individually responsible and passionately committed to as professionals. As a consequence of being existential, our philosophy and our commitment to it has an intellectual and moral aspect and because it reaches to the very depths of our raison d’être, it pertains to our passion as described by Søren Kierkegaard. This paper shall draw upon Dewey’s notion of wholeheartedness and Kierkegaard’s notion of purity of heart, to make the case that if educators embrace these in their practices, we may become more trustworthy. (shrink)

Though William Lane Craig believes his anti-Platonism is compatible with objective, Christian morality, I argue that it is not. First, I survey the main contours of his nominalism. Second, I discuss how he sees those points in relation to objective, Christian morality. Then, I argue that his view cannot sustain the qualitative aspects of moral virtues or principles, or even human beings. Moreover, Craig’s view loses any connection between those morals and humans, thereby doing great violence to objective, Christian morals. (...) Finally, I sketch two advantages of a Platonic realism in regards to Christian morals. (shrink)

The article examines the surprising role of Rousseau in the revival of liberal and humanist thought in contemporary French political thought. The choice of Rousseau as an inspiration and source of humanism is an illuminating indication of a shift in French thought. The authors concentrate on the natural- rights republicanism of Luc Ferry and Alain Renaut and the critical humanism of Tzvetan Todorov. While these thinkers all appeal to Rousseau's definition of humanity in terms of freedom, they draw on different (...) aspects of his thought and his relationship to the philosophic tradition. Their different receptions of Rousseau reveal tensions in the humanist revival and provoke reflection on the relationships among republicanism, liberalism and humanism in contemporary France. (shrink)

Many understand intentionality as the ofness or aboutness of mental states yet disagree about it metaphysically. I will argue that (1) intentionality seems best understood as an abstract universal; (2) it is needed to have factual knowledge of reality, yet (3) metaphysical treatments (or uses) of intentionality by several fashionable philosophies land us in constructivism. I will focus on Daniel Dennett’s treatment of intentionality and then extend my findings to other naturalist and physicalist views, postmodern epistemologies, and nominalism. I also (...) will sketch show how we use intentionality to know reality before suggesting an implication for epistemic externalism. (shrink)

For most of the church's history, people have seen Christian ethics as normative and universally applicable. Recently, however, this view has been lost, thanks to naturalism and relativism. R. Scott Smith argues that Christians need to overcome Kant's fact-value dichotomy and recover the possibility of genuine moral and theological knowledge.

Religion has surprised the secular elites of North American and European societies. Not only has religion survived the treacherous passage from village to metropolis, from medieval superstition to modern science, and from state support (and coercion) to voluntary membership. Apparently, it has thrived and gained new sources of strength amidst these transformations. Far from being relegated to the proverbial ash‐heap of history, modern religions and the activist movements they generate find themselves positioned at the centre of modern debates – and (...) modern wars – over territory, political sovereignty, human rights, global and local economy, scientific research and popular culture. Among these activist movements, the most virulent and sustained are ‘fundamentalisms’ – increasingly sophisticated reactions against secular modernity that seek to fight back against the enemies of traditional religion by constructing religiously inspired and quintessentially modern alternatives to ‘godless’, idolatrous governments, institutions and political and cultural elites. (shrink)

Merold Westphal and James K. A. Smith argue forcefully that Christians should embrace the postmodern turn to interpretation. They draw upon Derrida and Heidegger, and they criticize Edmund Husserl’s “metaphysics of presence” and our ability to know reality directly. They reject his epistemology as modern and arrogant, as an attempt to gain pristine knowledge. But I argue that they radically misunderstand and therefore wrongly reject Husserl. This will allow me to show why their view, that “everything is interpretation,” is mistaken. (...) It also will allow me to show why Husserl’s earlier work shows us how we can know reality immediately. (shrink)

In our times changes occur so rapidly that our modes of reading even more than our modes of analysis risk being inadequate, or in any case risk lagging behind. If we wish to analyze relations between the arts and the media, the danger is in fact that we will limit ourselves to established notions or even to stereotypes which are commonly accepted by the general public. Even for persons with some awareness, information remains lacunary. Moreover, like the experts, or those (...) who pass for such, it seems that it is difficult for them to avoid a personal conception, implicit or avowed, which does not fail to influence their judgement. This is almost always the case when the matter of art is raised, even if we take the precaution of placing the term in the plural. Whether one wishes to or not, there is hardly an example where certain preferences do not make themselves known. If it is easy to reach agreement with regard to the facts, it is less easy to agree on their interpretation, especially when values are at stake. Hence the necessity to proceed by different steps and explanations to explain the relationships between arts and the media. (shrink)

It is some 900 years before Christ that we find the most ancient traces of two innovations which were to have incalculable consequences for the future of mankind. The evolution of civilization has, in fact, been marked by a clean break located at the era when man discovered the rudiments of agriculture and animal husbandry and began to produce his own food. Whereas for the three million years during which he had to provide for his needs exclusively through hunting, fishing (...) and gathering, his progress was extremely slow, the adoption of a new way of life based on agriculture and animal husbandry allowed man to transform himself in less than twelve thousand years from deer hunter into astronaut. (shrink)

At first glance, the formulation of the principle of inertia—not. yet complete with Galileo, more precise with Gassendi, finally systematic with Newton—seems to constitute but one of the aspects of a process of deep transformations at the end of which traditional cosmology was replaced by various world systems. These transformations—or, to use a more classic term, this “ scientific revolution” —have been the object of numerous works, a list, of which would alone fill the pages of a thick volume. But (...) the principle of inertia itself, a principle about which can be said without exaggeration that it expressed the essence of this revolution at the same time as it stimulated it, has perhaps not received all the attention it deserves. And especially the impact of this principle on Western culture has not been fully measured. True, Alexandre Koyré has always insisted on the fact that, by reducing movement to a state like that of the state of rest, the principle of inertia expressed a new vision of the world more than a scientific result. But his admirable analyses deal more with the slow advent of the priciple of inertia among the natural philosophers who preceded, accompanied and then followed Galileo than with the theological, philosophical and literary impact of this principle. Moreover, by examining this impact, we discover that it is necessary to make a distinction between Euclidian space and absolute space, a distinction which is frequently implicit with certain scientific historians, but, and this must be emphasized, is more often ignored. (shrink)

In this essay, I revisit my claims about game structures and amend them by adding achievement-regulated games to previously analyzed time- and event-structured activities. In describing achievement formats, I discuss their heavy reliance on the world of work, their strong dependency on Suits’ lusory attitude, and their relative independence from constitutive rules. I argue that achievement-structured games carry disadvantages not shared by time- and event-regulated activities. I speculate that achievement gaming came first in our evolutionary history, but show that it (...) still holds value for modern players and spectators. (shrink)

This paper aims to offer an evaluation of Australia's National Framework for Values Education in terms of its educative value. The criteria to be employed in this evaluation shall be drawn primarily from the works of UNESCO and John Dewey. In addition to a re-evaluation of values, consideration will also be given to how individual learners are being prepared to participate democratically in the quest for world peace. It will therefore be necessary to determine whether the Australian framework promotes the (...) potential for democratic participation through inquiry or whether through schooling its overtly nationalistic agenda actually stifles the capacity of persons to participate in a pursuit for global understandings and world peace. (shrink)

Introduction -- Direct realism. An introduction to direct realism : the views of D.M. Armstrong -- The representationalism of Dretske, Tye, and Lycan -- Searle's naturalism and the prospects for knowledge -- Philosophy as science : neuroscience, neurophilosophy, and naturalized epistemology. Cognitive science, philosophy, and our knowledge of reality, pt. 1. The views of David Papineau -- Cognitive science, philosophy, and our knowledge of reality, pt. 2. The views of Daniel Dennett -- Can the Churchlands' neurocomputational theory cognition ground a (...) viable epistemology? (by Errin Clark) -- Other alternatives, and naturalism's future. Other proposals : Pollock's internalism, Kim's functionalism (with Peggy Burke), and more externalist considerations -- The future directions of naturalism -- A positive case for our knowledge of reality -- Methodological naturalism and the scientific method, and other implications. (shrink)